![]() The study was approved by the Renmin Hospital of Wuhan University Ethics Committee (approval number WDRY2020-K053). All the patients were diagnosed according to the clinical diagnosis standard by the WHO interim guidance, in which SARS-CoV-2 RNA was confirmed. Renmin Hospital of Wuhan University, which is located in the endemic areas of COVID-19, serves as an officially designated hospital. ![]() ![]() All patients were followed up until March 15, 2020. In this study, we presented the clinical features and outcomes estimated by overall survival in a cohort of elderly COVID-19 patients over 70 years old (yr).įor this retrospective study, we enrolled consecutive hospitalized patients over 70 yr from Renmin Hospital of Wuhan University in Wuhan, China, from January 20 to February 15, 2020. To the best of our knowledge, few studies focused on characterizing COVID-19 in elderly patients. reported that older males with comorbidities were more susceptible to COVID-19, and resulted in serious and life-threatening respiratory diseases. The outbreak has rapidly spread, and all ages can be easily infected. Severe organ dysfunction, including shock, acute respiratory distress syndrome (ARDS), acute heart injury, and acute kidney injury, can lead to death. The clinical features of those patients include fever, nonproductive cough, dyspnea, myalgia, fatigue, diarrhea, normal or decreased leukocyte count, and imaging evidence of pneumonia. As of October 9, 36,754,395 confirmed cases and 1,064,838 deaths were reported globally. On February 11, 2020, novel coronavirus-infected pneumonia (NCIP) was named, and then “COVID-19” by the WHO. In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 signified the third emergence of highly pathogenic coronavirus into the human. The epidemic of 2019 novel coronavirus disease (COVID-19) was first reported in Wuhan, China. The risk factors, including clinical subtypes and blood urea nitrogen greater than 9.5 mmol/L, could help physicians to identify elderly patients with poor clinical outcomes at an early stage. The patients over 70 yr with COVID-19 had a high case-fatality rate. Blood urea nitrogen greater than 9.5 mmol/L (HR = 2.805, 95% CI: 1.141–6.892, P = 0.025) on admission was an independent risk factor for death among laboratory findings. Multivariable Cox proportional hazard regression showed that clinical subtypes, including the severe type (HR = 2.983, 95% CI: 1.231–7.226, P = 0.016) and the critical type (HR = 3.267, 95%CI: 1.009–10.576, P = 0.048), were associated with increasing risk of death when compared with the general type. ![]() ResultsĪ total of 147 patients were enrolled. Univariable and multivariable Cox regression methods were used to explore the risk factors. Clinical data were compared between the two groups. Patients were classified into two groups: survivor and non-survivor groups. Clinical subtypes, including mild, moderate, severe, and critical types, were used to evaluate the severity of disease. Epidemiological, demographic, and clinical data were collected. In this retrospective study, we enrolled consecutively hospitalized patients over 70 yr with COVID-19 between January 20 and Februin Renmin Hospital of Wuhan University. We aimed to explore the risk factors associated with death in patients over 70 years old (yr). Elderly patients with COVID-19 were shown to have a high case-fatality rate.
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